Uroguanylin

guanylate cyclase activator 2B (uroguanylin)
Identifiers
Symbol GUCA2B
Entrez 2981
HUGO 4683
OMIM 601271
RefSeq NM_007102
UniProt Q16661
Other data
Locus Chr. 1 p34-p33
Uroguanylin
Identifiers
152175-68-3 YesY
3D model (Jmol) Interactive image
ChemSpider 4589972 YesY
MeSH uroguanylin
PubChem 5488765
Properties
C61H101N17O25S4
Molar mass 1,600.81 g·mol−1
Related compounds
Related compounds
PMDTA
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Uroguanylin is a 16 amino acid peptide that is secreted by enterochromaffin cells in the duodenum and proximal small intestine. Guanylin acts as an agonist of the guanylyl cyclase receptor GC-C and regulates electrolyte and water transport in intestinal and renal epithelia. Its sequence is H-Asn-Asp-Asp-Cys(1)-Glu-Leu-Cys(2)-Val-Asn-Val-Ala-Cys(1)-Thr-Gly-Cys(2)-Leu-OH.

In humans, the uroguanylin peptide is encoded by the GUCA2B gene.[1][2] Uroguanylin may be involved in appetite and perceptions of 'fullness' after eating meals, as suggested by a study into mice.[3]

See also

References

  1. Miyazato, M.; Nakazato, M.; Yamaguchi, H.; Date, Y.; Kojima, M.; Kangawa, K.; Matsuo, H.; Matsukura, S. (Feb 1996). "Cloning and characterization of a cDNA encoding a precursor for human uroguanylin.". Biochem Biophys Res Commun. 219 (2): 644–8. doi:10.1006/bbrc.1996.0287. PMID 8605041.
  2. Miyazato, M.; Nakazato, M.; Matsukura, S.; Kangawa, K.; Matsuo, H. (Aug 1997). "Genomic structure and chromosomal localization of human uroguanylin.". Genomics. 43 (3): 359–65. doi:10.1006/geno.1997.4808. PMID 9268639.
  3. Rahbi, H.; Narayan, H.; Jones, D.J.; Ng, L.L. (Dec 2012). "The uroguanylin system and human disease.". Clin. Sci. (Lond). 123 (12): 659–668. doi:10.1042/CS20120021. PMID 22877138.


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