Undecaprenyl-diphosphooligosaccharide-protein glycotransferase

Undecaprenyl-diphosphooligosaccharide-protein glycotransferase
Identifiers
EC number 2.4.99.19
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Undecaprenyl-diphosphooligosaccharide-protein glycotransferase (EC 2.4.99.19, PglB) is an enzyme with systematic name tritrans,heptacis-undecaprenyl-diphosphooligosaccharide:protein-L-asparagine N-beta-D-oligosaccharidotransferase.[1][2] This enzyme catalyses the following chemical reaction

tritrans,heptacis-undecaprenyl diphosphooligosaccharide + [protein]-L-asparagine tritrans,heptacis-undecaprenyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to protein L-asparagine

This is a bacterial enzyme that is isolated from Campylobacter jejuni and Campylobacter lari.

References

  1. Maita, N.; Nyirenda, J.; Igura, M.; Kamishikiryo, J.; Kohda, D. (2010). "Comparative structural biology of eubacterial and archaeal oligosaccharyltransferases". J. Biol. Chem. 285 (7): 4941–4950. doi:10.1074/jbc.M109.081752. PMID 20007322.
  2. Lizak, C.; Gerber, S.; Numao, S.; Aebi, M.; Locher, K.P. (2011). "X-ray structure of a bacterial oligosaccharyltransferase". Nature. 474: 350–355. doi:10.1038/nature10151. PMID 21677752.
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