UDP-N-acetyl-D-mannosamine dehydrogenase

UDP-N-acetyl-D-mannosamine dehydrogenase
Identifiers
EC number 1.1.1.336
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

UDP-N-acetyl-D-mannosamine dehydrogenase (EC 1.1.1.336, UDP-ManNAc 6-dehydrogenase, wecC (gene)) is an enzyme with systematic name UDP-N-acetyl-alpha-D-mannosamine:NAD+ 6-oxidoreductase.[1] This enzyme catalyses the following chemical reaction

UDP-N-acetyl-alpha-D-mannosamine + 2 NAD+ + H2O UDP-N-acetyl-alpha-D-mannosaminuronate + 2 NADH + 2 H+

This enzyme participates in acetamido sugar biosynthesis in bacteria and archaea.

References

  1. Namboori, S.C.; Graham, D.E. (2008). "Acetamido sugar biosynthesis in the Euryarchaea". J. Bacteriol. 190 (8): 2987–2996. doi:10.1128/JB.01970-07. PMC 2293230Freely accessible. PMID 18263721.
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