UDP-GlcNAc:ribostamycin N-acetylglucosaminyltransferase

UDP-GlcNAc:ribostamycin N-acetylglucosaminyltransferase
Identifiers
EC number 2.4.1.285
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

UDP-GlcNAc:ribostamycin N-acetylglucosaminyltransferase (EC 2.4.1.285, neoK (gene)) is an enzyme with systematic name UDP-N-acetyl-alpha-D-glucosamine:ribostamycin N-acetylglucosaminyltransferase.[1] This enzyme catalyses the following chemical reaction

UDP-N-acetyl-alpha-D-glucosamine + ribostamycin UDP + 2'''-acetyl-6'''-hydroxyneomycin C

Involved in biosynthesis of the aminoglycoside antibiotic neomycin.

References

  1. Yokoyama, K.; Yamamoto, Y.; Kudo, F.; Eguchi, T. (2008). "Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis". ChemBioChem. 9 (6): 865–869. doi:10.1002/cbic.200700717. PMID 18311744.
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