Trans-resveratrol di-O-methyltransferase

Trans-resveratrol di-O-methyltransferase
Identifiers
EC number 2.1.1.240
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Trans-resveratrol di-O-methyltransferase (EC 2.1.1.240, ROMT, resveratrol O-methyltransferase, pterostilbene synthase) is an enzyme with systematic name S-adenosyl-L-methionine:trans-resveratrol 3,5-O-dimethyltransferase.[1] This enzyme catalyses the following chemical reaction

2 S-adenosyl-L-methionine + trans-resveratrol 2 S-adenosyl-L-homocysteine + pterostilbene (overall reaction)
(1a) S-adenosyl-L-methionine + trans-resveratrol S-adenosyl-L-homocysteine + 3-methoxy-4',5-dihydroxy-trans-stilbene
(1b) S-adenosyl-L-methionine + 3-methoxy-4',5-dihydroxy-trans-stilbene S-adenosyl-L-homocysteine + pterostilbene

The enzyme catalyses the biosynthesis of pterostilbene from resveratrol.

References

  1. Schmidlin, L.; Poutaraud, A.; Claudel, P.; Mestre, P.; Prado, E.; Santos-Rosa, M.; Wiedemann-Merdinoglu, S.; Karst, F.; Merdinoglu, D.; Hugueney, P. (2008). "A stress-inducible resveratrol O-methyltransferase involved in the biosynthesis of pterostilbene in grapevine". Plant Physiol. 148: 1630–1639. doi:10.1104/pp.108.126003. PMID 18799660.
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