Terpentetriene synthase

Terpentetriene synthase
Identifiers
EC number 4.2.3.36
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Terpentetriene synthase (EC 4.2.3.36, Cyc2) is an enzyme with systematic name terpentedienyl-diphosphate diphosphate-lyase (terpentetriene-forming).[1][2][3] This enzyme catalyses the following chemical reaction

terpentedienyl diphosphate terpentetriene + diphosphate

This enzyme requires Mg2+ for maximal activity but can use Mn2+, Fe2+ or Co2+ to a lesser extent.

References

  1. Dairi, T.; Hamano, Y.; Kuzuyama, T.; Itoh, N.; Furihata, K.; Seto, H. (2001). "Eubacterial diterpene cyclase genes essential for production of the isoprenoid antibiotic terpentecin". J. Bacteriol. 183: 6085–6094. doi:10.1128/jb.183.20.6085-6094.2001. PMID 11567009.
  2. Hamano, Y.; Kuzuyama, T.; Itoh, N.; Furihata, K.; Seto, H.; Dairi, T. (2002). "Functional analysis of eubacterial diterpene cyclases responsible for biosynthesis of a diterpene antibiotic, terpentecin". J. Biol. Chem. 277: 37098–37104. doi:10.1074/jbc.m206382200. PMID 12138123.
  3. Eguchi, T.; Dekishima, Y.; Hamano, Y.; Dairi, T.; Seto, H.; Kakinuma, K. (2003). "A new approach for the investigation of isoprenoid biosynthesis featuring pathway switching, deuterium hyperlabeling, and 1H NMR spectroscopy. The reaction mechanism of a novel streptomyces diterpene cyclase". J. Org. Chem. 68: 5433–5438. doi:10.1021/jo026728a. PMID 12839434.
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