Taxoid 7beta-hydroxylase

Taxoid 7beta-hydroxylase
Identifiers
EC number 1.14.13.147
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Taxoid 7beta-hydroxylase (EC 1.14.13.147) is an enzyme with systematic name taxusin,NADPH:oxygen 7-oxidoreductase.[1] This enzyme catalyses the following chemical reaction

taxusin + O2 + NADPH + H+ 7beta-hydroxytaxusin + NADP+ + H2O

Taxoid 7beta-hydroxylase requires cytochrome P450.

References

  1. Chau, M.; Jennewein, S.; Walker, K.; Croteau, R. (2004). "Taxol biosynthesis: Molecular cloning and characterization of a cytochrome P450 taxoid 7 β-hydroxylase". Chem. Biol. 11 (5): 663–672. doi:10.1016/j.chembiol.2004.02.025. PMID 15157877.
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