TRNA (guanine6-N2)-methyltransferase

TRNA (guanine6-N2)-methyltransferase
Identifiers
EC number 2.1.1.256
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

TRNA (guanine6-N2)-methyltransferase (EC 2.1.1.256, methyltransferase Trm14, m2G6 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine6-N2)-methyltransferase.[1] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanine6 in tRNA S-adenosyl-L-homocysteine + N2-methylguanine6 in tRNA

The enzyme specifically methylates guanine6 at N2 in tRNA.

References

  1. Menezes, S.; Gaston, K.W.; Krivos, K.L.; Apolinario, E.E.; Reich, N.O.; Sowers, K.R.; Limbach, P.A.; Perona, J.J. (2011). "Formation of m2G6 in Methanocaldococcus jannaschii tRNA catalyzed by the novel methyltransferase Trm14". Nucleic Acids Res. 39: 7641–7655. doi:10.1093/nar/gkr475. PMID 21693558.
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