TRNA (cytidine32/uridine32-2'-O)-methyltransferase

TRNA (cytidine32/uridine32-2'-O)-methyltransferase
Identifiers
EC number 2.1.1.200
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

TRNA (cytidine32/uridine32-2'-O)-methyltransferase (EC 2.1.1.200, YfhQ, tRNA:Cm32/Um32 methyltransferase, TrMet(Xm32), TrmJ) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (cytidine32/uridine32-2'-O)-methyltransferase.[1] This enzyme catalyses the following chemical reaction

(1) S-adenosyl-L-methionine + cytidine32 in tRNA S-adenosyl-L-homocysteine + 2'-O-methylcytidine32 in tRNA
(2) S-adenosyl-L-methionine + uridine32 in tRNA S-adenosyl-L-homocysteine + 2'-O-methyluridine32 in tRNA

In Escherichia coli YfhQ is the only methyltransferase responsible for the formation of 2'-O-methylcytidine32 in tRNA.

References

  1. Purta, E.; van Vliet, F.; Tkaczuk, K.L.; Dunin-Horkawicz, S.; Mori, H.; Droogmans, L.; Bujnicki, J.M. (2006). "The yfhQ gene of Escherichia coli encodes a tRNA:Cm32/Um32 methyltransferase". BMC Mol. Biol. 7: #23–23. doi:10.1186/1471-2199-7-23. PMC 1569432Freely accessible. PMID 16848900.
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