TRNA (cytidine32/guanosine34-2'-O)-methyltransferase

TRNA (cytidine32/guanosine34-2'-O)-methyltransferase
Identifiers
EC number 2.1.1.205
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

TRNA (cytidine32/guanosine34-2'-O)-methyltransferase (EC 2.1.1.205, Trm7p) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (cytidine32/guanosine34-2'-O)-methyltransferase.[1] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + cytidine32/guanosine34 in tRNA S-adenosyl-L-homocysteine + 2'-O-methylcytidine32/2'-O-methylguanosine34 in tRNA

The enzyme from Saccharomyces cerevisiae catalyses the formation of 2'-O-methylnucleotides at positions 32 and 34 of the yeast tRNAPhe and tRNATrp.

References

  1. Pintard, L.; Lecointe, F.; Bujnicki, J.M.; Bonnerot, C.; Grosjean, H.; Lapeyre, B. (2002). "Trm7p catalyses the formation of two 2-O-methylriboses in yeast tRNA anticodon loop". EMBO J. 21: 1811–1820. doi:10.1093/emboj/21.7.1811. PMID 11927565.
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