TRNA1Val (adenine37-N6)-methyltransferase

TRNA1Val (adenine37-N6)-methyltransferase
Identifiers
EC number 2.1.1.223
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

TRNA1Val (adenine37-N6)-methyltransferase (EC 2.1.1.223, YfiC) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA1Val (adenine37-N6)-methyltransferase.[1] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + adenine37 in tRNA1Val S-adenosyl-L-homocysteine + N6-methyladenine37 in tRNA1Val

The enzyme specifically methylates adenine37 in tRNA1Val (anticodon cmo5UAC).

References

  1. Golovina, A.Y.; Sergiev, P.V.; Golovin, A.V.; Serebryakova, M.V.; Demina, I.; Govorun, V.M.; Dontsova, O.A. (2009). "The yfiC gene of E. coli encodes an adenine-N6 methyltransferase that specifically modifies A37 of tRNA1Val(cmo5UAC)". RNA. 15: 1134–1141. doi:10.1261/rna.1494409. PMID 19383770.
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