TRNA-dihydrouridine20a/20b synthase (NAD(P)+)

TRNA-dihydrouridine20a/20b synthase (NAD(P)+)
Identifiers
EC number 1.3.1.90
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

TRNA-dihydrouridine20a/20b synthase (NAD(P)+) (EC 1.3.1.90, Dus4p) is an enzyme with systematic name tRNA-5,6-dihydrouracil20a/20b:NAD(P)+ oxidoreductase.[1] This enzyme catalyses the following chemical reaction

(1) 5,6-dihydrouracil20a in tRNA + NAD(P)+ uracil20a in tRNA + NAD(P)H + H+
(2) 5,6-dihydrouracil20b in tRNA + NAD(P)+ uracil20b in tRNA + NAD(P)H + H+

A flavoenzyme. The enzyme specifically modifies uracil20a and uracil20b in tRNA.

References

  1. Xing, F.; Hiley, S.L.; Hughes, T.R.; Phizicky, E.M. (2004). "The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs". J. Biol. Chem. 279: 17850–17860. doi:10.1074/jbc.M401221200. PMID 14970222.
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