Sulfite reductase (NADPH)

Sulfite reductase (NADPH)
Identifiers
EC number 1.8.1.2
CAS number 9029-35-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Sulfite reductase (NADPH) (EC 1.8.1.2, sulfite (reduced nicotinamide adenine dinucleotide phosphate) reductase, NADPH-sulfite reductase, NADPH-dependent sulfite reductase, H2S-NADP oxidoreductase, sulfite reductase (NADPH2)) is an enzyme with systematic name hydrogen-sulfide:NADP+ oxidoreductase.[1][2][3] This enzyme catalises the following chemical reaction

hydrogen sulfide + 3 NADP+ + 3 H2O sulfite + 3 NADPH + 3 H+

Sulfite reductase is an iron flavoprotein (FAD and FMN).

References

  1. Hilz, H.; Kittler, M.; Knape, G. (1959). "Die Reduktion von Sulfate in der Hefe". Biochem. Z. 332: 151–166. PMID 14401842.
  2. Siegel, L.M.; Murphy, M.J.; Kamin, H. (1973). "Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. I. The Escherichia coli hemoflavoprotein: molecular parameters and prosthetic groups". J. Biol. Chem. 248: 251–264. PMID 4144254.
  3. Yoshimoto, A.; Sato, R. (1968). "Studies on yeast sulfite reductase. I. Purification and characterization". Biochim. Biophys. Acta. 153: 555–575. doi:10.1016/0005-2728(68)90185-0. PMID 4384979.
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