Signal peptidase I
| Signal peptidase I | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.21.89 | ||||||||
| CAS number | 65979-36-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Signal peptidase I (EC 3.4.21.89, leader peptidase I, signal proteinase, Escherichia coli leader peptidase, eukaryotic signal peptidase, eukaryotic signal proteinase, leader peptidase, leader peptide hydrolase, leader proteinase, signal peptidase, pilin leader peptidase, SPC, prokaryotic signal peptidase, prokaryotic leader peptidase, HOSP, prokaryotic signal proteinase, propeptidase, PuIO prepilin peptidase, signal peptide hydrolase, signal peptide peptidase, signalase, bacterial leader peptidase 1) is an enzyme.[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction
- Cleavage of hydrophobic, N-terminal signal or leader sequences
This enzyme is present in bacterial membranes and in chloroplast thylakoid membranes.
References
- ↑ Black, M.T. (1993). "Evidence that the catalytic activity of prokaryote leader peptidase depends upon the operation of a serine-lysine catalytic dyad". J. Bacteriol. 175 (16): 4957–4961. PMID 8394311.
- ↑ Nunnari, J.; Fox, T.D.; Walter, P. (1993). "A mitochondrial protease with two catalytic subunits of nonoverlapping specificities". Science. 262 (5142): 1997–2004. doi:10.1126/science.8266095. PMID 8266095.
- ↑ Tschantz, W.R.; Sung, M.; Delgado-Partin, V.M.; Dalbey, R.E. (1993). "A serine and a lysine residue implicated in the catalytic mechanism of the Escherichia coli leader peptidase". J. Biol. Chem. 268 (36): 27349–27354. PMID 8262975.
- ↑ Lively, M.O.; Newsome, A.L.; Nusier, M. (1994). "Eukaryote microsomal signal peptidases". Methods Enzymol. 244: 301–314. doi:10.1016/0076-6879(94)44024-7. PMID 7845216.
- ↑ Tschantz, W.R.; Dalbey, R.E. (1994). "Bacterial leader peptidase I". Methods Enzymol. 244: 285–301. doi:10.1016/0076-6879(94)44023-9. PMID 7845215.
- ↑ Chaal, B.K.; Mould, R.M.; Barbrook, A.C.; Gray, J.C.; Howe, C.J. (1998). "Characterization of a cDNA encoding the thylakoidal processing peptidase from Arabidopsis thaliana. Implications for the origin and catalytic mechanism of the enzyme". J. Biol. Chem. 273 (2): 689–692. doi:10.1074/jbc.273.2.689. PMID 9422718.
- ↑ Inoue, K.; Baldwin, A.J.; Shipman, R.L.; Matsui, K.; Theg, S.M.; Ohme-Takagi, M. (2005). "Complete maturation of the plastid protein translocation channel requires a type I signal peptidase". J. Cell Biol. 171: 425–430. doi:10.1083/jcb.200506171. PMID 16275749.
External links
- Signal peptidase I at the US National Library of Medicine Medical Subject Headings (MeSH)
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