SPRY1

Identifiers

SPRY1, hsprouty RTK signaling antagonist 1

External IDs

MGI: 1345139 HomoloGene: 4266 GeneCards: SPRY1

Gene ontology
Molecular function	• protein binding
Cellular component	• Golgi apparatus • membrane • plasma membrane • nucleoplasm • cytosol • cytoplasm
Biological process	• ureteric bud development • negative regulation of neurotrophin TRK receptor signaling pathway • negative regulation of epidermal growth factor receptor signaling pathway • organ induction • bud elongation involved in lung branching • negative regulation of Ras protein signal transduction • multicellular organism development • negative regulation of fibroblast growth factor receptor signaling pathway • negative regulation of GTPase activity • regulation of signal transduction • negative regulation of MAP kinase activity • establishment of mitotic spindle orientation • metanephros development • negative regulation of cell proliferation • negative regulation of ERK1 and ERK2 cascade
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


10252


24063

Ensembl


ENSG00000164056


ENSMUSG00000037211

UniProt


O43609


Q9QXV9

RefSeq (mRNA)


NM_001258038 NM_001258039 NM_005841 NM_199327


NM_011896 NM_001305440 NM_001305441 NM_001305442

RefSeq (protein)


NP_001244967.1 NP_001244968.1 NP_005832.1 NP_955359.1


NP_001292369.1 NP_001292370.1 NP_001292371.1 NP_036026.1

Location (UCSC)

Chr 4: 123.4 – 123.4 Mb

Chr 3: 37.64 – 37.64 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Protein sprouty homolog 1 is a protein that in humans is encoded by the SPRY1 gene.^[3]^[4]^[5]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Hacohen N, Kramer S, Sutherland D, Hiromi Y, Krasnow MA (Feb 1998). "sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways". Cell. 92 (2): 253–63. doi:10.1016/S0092-8674(00)80919-8. PMID 9458049.
↑ Haglund K, Schmidt MH, Wong ES, Guy GR, Dikic I (Jul 2005). "Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation". EMBO Rep. 6 (7): 635–41. doi:10.1038/sj.embor.7400453. PMC 1369112. PMID 15962011.
↑ "Entrez Gene: SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)".

Lim J, Wong ES, Ong SH, et al. (2000). "Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain.". J. Biol. Chem. 275 (42): 32837–45. doi:10.1074/jbc.M002156200. PMID 10887178.
Egan JE, Hall AB, Yatsula BA, Bar-Sagi D (2002). "The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins.". Proc. Natl. Acad. Sci. U.S.A. 99 (9): 6041–6. doi:10.1073/pnas.052090899. PMC 122898. PMID 11983899.
Hanafusa H, Torii S, Yasunaga T, Nishida E (2004). "Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.". Nat. Cell Biol. 4 (11): 850–8. doi:10.1038/ncb867. PMID 12402043.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Di Y, Li J, Zhang Y, et al. (2004). "HCC-associated protein HCAP1, a variant of GEMIN4, interacts with zinc-finger proteins.". J. Biochem. 133 (6): 713–8. doi:10.1093/jb/mvg091. PMID 12869526.
Wang L, Ji C, Wu H, et al. (2004). "Identification and expression analysis of a novel splice variant of human Sprouty1 gene.". Int. J. Mol. Med. 12 (5): 783–7. doi:10.3892/ijmm.12.5.783. PMID 14533010.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Anteby EY, Natanson-Yaron S, Greenfield C, et al. (2005). "Human placental Hofbauer cells express sprouty proteins: a possible modulating mechanism of villous branching.". Placenta. 26 (6): 476–83. doi:10.1016/j.placenta.2004.08.008. PMID 15950061.
Cabrita MA, Jäggi F, Widjaja SP, Christofori G (2006). "A functional interaction between sprouty proteins and caveolin-1.". J. Biol. Chem. 281 (39): 29201–2912. doi:10.1074/jbc.M603921200. PMID 16877379.
Fritzsche S, Kenzelmann M, Hoffmann MJ, et al. (2007). "Concomitant down-regulation of SPRY1 and SPRY2 in prostate carcinoma.". Endocr. Relat. Cancer. 13 (3): 839–49. doi:10.1677/erc.1.01190. PMID 16954433.
Schaaf G, Hamdi M, et al. (2010). "Silencing of SPRY1 triggers complete regression of rhabdomyosarcoma tumors carrying a mutated RAS gene.". Cancer Research. 70 (2): 762–71. doi:10.1158/0008-5472.CAN-09-2532. PMID 20068162.
Nathan J Charles; Robert C Huebert; Sangjin Lee; Neeta Adhikari; Sean Polster; James E Rider; Elizabeth Braunlin; Ami Mariash; Maggie Robledo; David Schuweiler & Jennifer L Hall (2010). "Targeted Sprouty1 overexpression in cardiac myocytes does not alter myocardial remodeling or function.". Mol Cell Biochem. 342 (1,2): 57–62. doi:10.1007/s11010-010-0468-8. PMC 2923832. PMID 20461448.

External links

SPRY1 human gene location in the UCSC Genome Browser.
SPRY1 human gene details in the UCSC Genome Browser.

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SPRY1

See also

References

Further reading

External links