S-methyl-5'-thioinosine phosphorylase

S-methyl-5'-thioinosine phosphorylase
Identifiers
EC number 2.4.2.44
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

S-methyl-5'-thioinosine phosphorylase (EC 2.4.2.44, MTIP, MTI phosphorylase, methylthioinosine phosphorylase) is an enzyme with systematic name S-methyl-5'-thioinosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase.[1] This enzyme catalyses the following chemical reaction

S-methyl-5'-thioinosine + phosphate hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate

The catabolism of 5'-methylthioadenosine in Pseudomonas aeruginosa involves deamination to S-methyl-5'-thioinosine (EC 3.5.4.31, S-methyl-5'-thioadenosine deaminase) and phosphorolysis to hypoxanthine.

References

  1. Guan, R.; Ho, M.C.; Almo, S.C.; Schramm, V.L. (2011). "Methylthioinosine phosphorylase from Pseudomonas aeruginosa. Structure and annotation of a novel enzyme in quorum sensing". Biochemistry. 50: 1247–1254. doi:10.1021/bi101642d. PMID 21197954.
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