Purine imidazole-ring cyclase
| purine imidazole-ring cyclase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.3.2.4 | ||||||||
| CAS number | 95990-28-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
| |||||||||
In enzymology, a purine imidazole-ring cyclase (EC 4.3.2.4) is an enzyme that catalyzes the chemical reaction
- DNA 4,6-diamino-5-formamidopyrimidine DNA adenine + H2O
Hence, this enzyme has one substrate, DNA 4,6-diamino-5-formamidopyrimidine, and two products, DNA adenine and H2O.
This enzyme belongs to the family of lyases, specifically amidine lyases. The systematic name of this enzyme class is DNA-4,6-diamino-5-formamidopyrimidine C8-N9-lyase (cyclizing DNA-adenine-forming). Other names in common use include DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing), DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing, and DNA-adenine-forming).
References
- Chetsanga CJ, Grigorian C (1985). "In situ enzymatic reclosure of opened imidazole rings of purines in DNA damaged by gamma-irradiation". Proc. Natl. Acad. Sci. U.S.A. 82 (3): 633–7. doi:10.1073/pnas.82.3.633. PMC 397099
. PMID 3856219.
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