Protein-fructosamine 3-kinase

Protein-fructosamine 3-kinase
Identifiers
EC number 2.7.1.171
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Protein-fructosamine 3-kinase (EC 2.7.1.171, FN3K, fructosamine 3-kinase) is an enzyme with systematic name ATP:(protein)-N6-D-fructosyl-L-lysine 3-phosphotransferase.[1][2] This enzyme catalyses the following chemical reaction

ATP + [protein]-N6-D-fructosyl-L-lysine ADP + [protein]-N6-(3-O-phospho-D-fructosyl)-L-lysine

Nonenzymatic glycation is a factor in the pathogenesis of diabetes.

References

  1. Szwergold, B.S.; Howell, S.; Beisswenger, P.J. (2001). "Human fructosamine-3-kinase: purification, sequencing, substrate specificity, and evidence of activity in vivo". Diabetes. 50: 2139–2147. doi:10.2337/diabetes.50.9.2139. PMID 11522682.
  2. Delpierre, G.; Rider, M.H.; Collard, F.; Stroobant, V.; Vanstapel, F.; Santos, H.; Van Schaftingen, E. (2000). "Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase". Diabetes. 49: 1627–1634. doi:10.2337/diabetes.49.10.1627. PMID 11016445.
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