Plasmepsin I

Plasmepsin I
Identifiers
EC number 3.4.23.38
CAS number 180189-87-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Plasmepsin I (EC 3.4.23.38, aspartic hemoglobinase I, PFAPG, malaria aspartic hemoglobinase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Hydrolysis of the -Phe33-Leu- bond in the alpha-chain of hemoglobin, leading to denaturation of the molecule

This enzyme is present in the malaria organism, Plasmodium.

References

  1. Goldberg, D.E.; Slater, A.F.G.; Beavis, R.; Chait, B.; Cerami, A.; Henderson, G.B. (1991). "Hemoglobin degradation in the human malaria pathogen Plasmodium falciparum: a catabolic pathway initiated by a specific aspartic protease". J. Exp. Med. 173 (4): 961–969. doi:10.1084/jem.173.4.961. PMID 2007860.
  2. Francis, S.E.; Gluzman, I.Y.; Oksman, A.; Knickerbocker, A.; Mueller, R.; Bryant, M.L.; Sherman, D.R.; Russell, D.G.; Goldberg, D.E. (1994). "Molecular characterization and inhibition of a Plasmodium falciparum aspartic hemoglobinase". EMBO J. 13 (2): 306–317. PMID 8313875.
  3. Gluzman, I.Y.; Francis, S.E.; Oksman, A.; Smith, C.E.; Duffin, K.L.; Goldberg, D.E. (1994). "Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway". J. Clin. Invest. 93: 1602–1608. doi:10.1172/JCI117140. PMID 8163662.
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