Phenylalanine N-monooxygenase

Phenylalanine N-monooxygenase
Identifiers
EC number 1.14.13.124
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Phenylalanine N-monooxygenase (EC 1.14.13.124, phenylalanine N-hydroxylase, CYP79A2) is an enzyme with systematic name L-phenylalanine,NADPH:oxygen oxidoreductase (N-hydroxylating).[1] This enzyme catalyses the following chemical reaction

L-phenylalanine + 2 O2 + 2 NADPH + 2 H+ (E)-phenylacetaldoxime + 2 NADP+ + CO2 + 3 H2O (overall reaction)
(1a) L-phenylalanine + O2 + NADPH + H+ N-hydroxy-L-phenylalanine + NADP+ + H2O:
(1b) N-hydroxy-L-phenylalanine + O2 + NADPH + H+ N,N-dihydroxy-L-phenylalanine + NADP+ + H2O
(1c) N,N-dihydroxy-L-phenylalanine (E)-phenylacetaldoxime + CO2 + H2O

Phenylalanine N-monooxygenase is a heme-thiolate protein (P-450).

References

  1. Wittstock, U.; Halkier, B.A. (2000). "Cytochrome P450 CYP79A2 from Arabidopsis thaliana L. Catalyzes the conversion of L-phenylalanine to phenylacetaldoxime in the biosynthesis of benzylglucosinolate". J. Biol. Chem. 275: 14659–14666. doi:10.1074/jbc.275.19.14659. PMID 10799553.
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