O-sialoglycoprotein endopeptidase

O-sialoglycoprotein endopeptidase
Identifiers
EC number 3.4.24.57
CAS number 129430-53-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

O-sialoglycoprotein endopeptidase (EC 3.4.24.57, glycoprotease, glycophorin A proteinase, glycoproteinase, sialoglycoprotease, sialoglycoproteinase, "OSGE") is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Hydrolysis of O-sialoglycoproteins; cleaves -Arg31-Asp- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated

This enzyme is secreted by the bacterium Pasteurella haemolytica.

References

  1. Abdullah, K.M.; Lo, R.Y.C.; Mellors, A. (1991). "Cloning, nucleotide sequence, and expression of the Pasteurella haemolytica A1 glycoprotease gene". J. Bacteriol. 173: 5597–5603. PMID 1885539.
  2. Abdullah, K.M.; Udoh, E.A.; Shewen, P.E.; Mellors, A. (1992). "A neutral glycoprotease of Pasteurella haemolytica A1 specifically cleaves O-sialoglycoproteins". Infect. Immun. 60: 56–62. PMID 1729196.
  3. Sutherland, D.R.; Abdullah, K.M.; Cyopick, P.; Mellors, A. (1992). "Cleavage of the cell-surface O-sialoglycoproteins CD34, CD43, CD44, and CD45 by a novel glycoprotease from Pasteurella haemolytica". J. Immunol. 148: 1458–1464. PMID 1371528.
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