O-phosphoseryl-tRNASec kinase

O-phosphoseryl-tRNASec kinase
Identifiers
EC number 2.7.1.164
CAS number 91273-83-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

O-phosphoseryl-tRNASec kinase (EC 2.7.1.164, PSTK, phosphoseryl-tRNA[Ser]Sec kinase, phosphoseryl-tRNASec kinase) is an enzyme with systematic name ATP:L-seryl-tRNASec O-phosphotransferase.[1][2][3] This enzyme catalyses the following chemical reaction

ATP + L-seryl-tRNASec ADP + O-phospho-L-seryl-tRNASec

In archaea and eukarya selenocysteine formation is achieved by a two-step process.

References

  1. Carlson, B.A.; Xu, X.M.; Kryukov, G.V.; Rao, M.; Berry, M.J.; Gladyshev, V.N.; Hatfield, D.L. (2004). "Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase". Proc. Natl. Acad. Sci. USA. 101 (35): 12848–12853. doi:10.1073/pnas.0402636101. PMID 15317934.
  2. Sherrer, R.L.; O'Donoghue, P.; Soll, D. (2008). "Characterization and evolutionary history of an archaeal kinase involved in selenocysteinyl-tRNA formation". Nucleic Acids Res. 36: 1247–1259. doi:10.1093/nar/gkm1134. PMID 18174226.
  3. Khangulov, S.V.; Gladyshev, V.N.; Dismukes, G.C.; Stadtman, T.C. (1998). "Selenium-containing formate dehydrogenase H from Escherichia coli: a molybdopterin enzyme that catalyzes formate oxidation without oxygen transfer". Biochemistry. 37: 3518–3528. doi:10.1021/bi972177k. PMID 9521673.
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