O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Identifiers
EC number 2.4.1.222
CAS number 299203-70-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

In enzymology, an O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (EC 2.4.1.222) is an enzyme that catalyzes the chemical reaction in which a beta-D-GlcNAc residue is transferred from UDP-D-GlcNAc to the fucose residue of a fucosylated protein.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-D-GlcNAc:O-L-fucosylpeptide 3-beta-N-acetyl-D-glucosaminyltransferase. This enzyme is also called O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase. This enzyme participates in notch signaling pathway.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2J0A and 2J0B.

References


    This article is issued from Wikipedia - version of the 8/10/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.