N,N'-diacetyllegionaminate synthase

N,N'-diacetyllegionaminate synthase
Identifiers
EC number 2.5.1.101
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

N,N'-diacetyllegionaminate synthase (EC 2.5.1.101, neuB (gene), legI (gene)) is an enzyme with systematic name phosphenolpyruvate:2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose 1-(2-carboxy-2-oxoethyl)transferase.[1][2] This enzyme catalyses the following chemical reaction

2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + phosphenolpyruvate + H2O N,N'-diacetyllegionaminate + phosphate

This enzyme requires a divalent metal such as Mn2+.

References

  1. Glaze, P.A.; Watson, D.C.; Young, N.M.; Tanner, M.E. (2008). "Biosynthesis of CMP-N,N-diacetyllegionaminic acid from UDP-N,N-diacetylbacillosamine in Legionella pneumophila". Biochemistry. 47 (10): 3272–3282. doi:10.1021/bi702364s. PMID 18275154.
  2. Schoenhofen, I.C.; Vinogradov, E.; Whitfield, D.M.; Brisson, J.R.; Logan, S.M. (2009). "The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors". Glycobiology. 19 (7): 715–725. doi:10.1093/glycob/cwp039. PMID 19282391.
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