Meprin B

Meprin B
Identifiers
EC number 3.4.24.63
CAS number 150679-52-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Meprin B (EC 3.4.24.63, meprin-b) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction

Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of -His5-Leu-, -Leu6-Cys-, -Ala14-Leu- and -Cys19-Gly- bonds in insulin B chain

This membrane-bound metalloendopeptidase is present in mouse intestines.

References

  1. Kounnas, M.Z.; Wolz, R.L.; Gorbea, C.M.; Bond, J.S. (1991). "Meprin-A and -B. Cell surface endopeptidases of the mouse kidney". J. Biol. Chem. 266: 17350–17357. PMID 1894622.
  2. Gorbea, C.M.; Marchand, P.; Jiang, W.; Copeland, N.G.; Gilbert, D.J.; Jenkins, N.A.; Bond, J.S. (1993). "Cloning, expression, and chromosomal localization of the mouse meprin β subunit". J. Biol. Chem. 268: 21035–21043. PMID 8407940.
  3. Johnson, G.D.; Hersh, L.B. (1994). "Expression of meprin subunit precursors. Membrane anchoring through the β subunit and mechanism of zymogen activation". J. Biol. Chem. 269: 7682–7688. PMID 7510289.
  4. Wolz, R.L.; Bond, J.S. (1995). "Meprins A and B". Methods Enzymol. 248: 325–345. doi:10.1016/0076-6879(95)48022-6. PMID 7674930.
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