Memapsin 1
| Memapsin 1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.23.45 | ||||||||
| CAS number | 447457-31-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Memapsin 1 (EC 3.4.23.45, beta-secretase, beta-site Alzheimer's amyloid precursor protein cleaving enzyme 2 (BACE2), ASP1, Down region aspartic protease) is an enzyme.[1] This enzyme catalyses the following chemical reaction
- Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu!Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein
This enzyme belongs to the peptidase family A1.
References
- ↑ Turner, R.T.; Loy, J.A.; Nguyen, C.; Devasamudram, T.; Ghosh, A.K.; Koelsch, G.; Tang, J. (2002). "Specificity of memapsin 1 and its implications on the design of memapsin 2 (β-secretase) inhibitor selectivity". Biochemistry. 41: 8742–8746. doi:10.1021/bi025926t. PMID 12093293.
External links
- Memapsin 1 at the US National Library of Medicine Medical Subject Headings (MeSH)
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