KMT2E

KMT2E
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases KMT2E, HDCMC04P, MLL5, NKp44L, lysine methyltransferase 2E
External IDs MGI: 1924825 HomoloGene: 18822 GeneCards: KMT2E
Orthologs
Species Human Mouse
Entrez

55904

69188

Ensembl

ENSG00000005483

ENSMUSG00000029004

UniProt

Q8IZD2

Q3UG20

RefSeq (mRNA)

NM_018682
NM_032187
NM_182931

NM_026984

RefSeq (protein)

NP_061152.3
NP_891847.1

NP_081260.1

Location (UCSC) Chr 7: 105.01 – 105.11 Mb Chr 5: 23.43 – 23.5 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Lysine methyltransferase 2E is a protein that in humans is encoded by the KMT2E gene. [3]

Function

This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a protein with an N-terminal PHD zinc finger and a central SET domain. Overexpression of the protein inhibits cell cycle progression. Alternate transcriptional splice variants have been characterized.

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ "Entrez Gene: Lysine methyltransferase 2E". Retrieved 2016-06-02.

Further reading

  • Emerling BM, Bonifas J, Kratz CP, Donovan S, Taylor BR, Green ED, Le Beau MM, Shannon KM (2002). "MLL5, a homolog of Drosophila trithorax located within a segment of chromosome band 7q22 implicated in myeloid leukemia". Oncogene. 21 (31): 4849–54. doi:10.1038/sj.onc.1205615. PMID 12101424. 


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia - version of the 6/2/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.