METTL3

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
5IL0, 5IL2, 5IL1, 5K7M, 5K7U, 5K7W

Identifiers

Aliases

METTL3, IME4, M6A, MT-A70, Spo8, methyltransferase like 3

External IDs

MGI: 1927165 HomoloGene: 10501 GeneCards: METTL3

Gene ontology
Molecular function	• methyltransferase activity • transferase activity • RNA binding • RNA methyltransferase activity • mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity • mRNA binding • S-adenosyl-L-methionine binding • protein heterodimerization activity
Cellular component	• MIS complex • nucleoplasm • nuclear speck • nucleus • cytoplasm
Biological process	• mRNA splicing, via spliceosome • gene expression • rhythmic process • mRNA processing • positive regulation of cap-independent translational initiation • stem cell population maintenance • primary miRNA methylation • methylation • mRNA methylation • mRNA destabilization • circadian rhythm • primary miRNA processing • nucleobase-containing compound metabolic process • adenosine to inosine editing • RNA methylation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


56339


56335

Ensembl


ENSG00000165819


ENSMUSG00000022160

UniProt


Q86U44


Q8C3P7

RefSeq (mRNA)


NM_019852


NM_019721

RefSeq (protein)


NP_062826.2


NP_062695.2

Location (UCSC)

Chr 14: 21.5 – 21.51 Mb

Chr 14: 52.29 – 52.31 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

N6-adenosine-methyltransferase 70 kDa subunit is an enzyme that in humans is encoded by the METTL3 gene.^[3]

This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.^[3]

References

Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bujnicki JM, Feder M, Radlinska M, Blumenthal RM (2003). "Structure prediction and phylogenetic analysis of a functionally diverse family of proteins homologous to the MT-A70 subunit of the human mRNA:m(6)A methyltransferase". J. Mol. Evol. 55 (4): 431–44. doi:10.1007/s00239-002-2339-8. PMID 12355263.
Leach RA, Tuck MT (2001). "Expression of the mRNA (N6-adenosine)-methyltransferase S-adenosyl-L-methionine binding subunit mRNA in cultured cells". Int. J. Biochem. Cell Biol. 33 (10): 984–99. doi:10.1016/S1357-2725(01)00071-1. PMID 11470232.
Bokar JA, Shambaugh ME, Polayes D, et al. (1998). "Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase". RNA. 3 (11): 1233–47. PMC 1369564. PMID 9409616.

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METTL3

References

Further reading