Lipid IVA 3-deoxy-D-manno-octulosonic acid transferase
| Lipid IVA 3-deoxy-D-manno-octulosonic acid transferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.4.99.12 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Lipid IVA 3-deoxy-D-manno-octulosonic acid transferase (EC 2.4.99.12, KDO transferase, waaA (gene), kdtA (gene), 3-deoxy-D-manno-oct-2-ulosonic acid transferase, 3-deoxy-manno-octulosonic acid transferase, lipid IVA KDO transferase) is an enzyme with systematic name CMP-3-deoxy-D-manno-oct-2-ulosonate:lipid IVA 3-deoxy-D-manno-oct-2-ulosonate transferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- lipid IVA + CMP-alpha-Kdo alpha-Kdo-(2->6)-lipid IVA + CMP
The bifunctional enzyme from Escherichia coli transfers two 3-deoxy-D-manno-oct-2-ulosonate residues to lipid IVA.
See also
- EC 2.4.99.13, (KDO)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase
References
- ↑ Belunis, C.J.; Raetz, C.R. (1992). "Biosynthesis of endotoxins. Purification and catalytic properties of 3-deoxy-D-manno-octulosonic acid transferase from Escherichia coli". J. Biol. Chem. 267 (14): 9988–9997. PMID 1577828.
- ↑ Mamat, U.; Schmidt, H.; Munoz, E.; Lindner, B.; Fukase, K.; Hanuszkiewicz, A.; Wu, J.; Meredith, T.C.; Woodard, R.W.; Hilgenfeld, R.; Mesters, J.R.; Holst, O. (2009). "WaaA of the hyperthermophilic bacterium Aquifex aeolicus is a monofunctional 3-deoxy-D-manno-oct-2-ulosonic acid transferase involved in lipopolysaccharide biosynthesis". J. Biol. Chem. 284 (33): 22248–22262. doi:10.1074/jbc.M109.033308. PMC 2755949
. PMID 19546212. - ↑ White, K.A.; Kaltashov, I.A.; Cotter, R.J.; Raetz, C.R. (1997). "A mono-functional 3-deoxy-D-manno-octulosonic acid (Kdo) transferase and a Kdo kinase in extracts of Haemophilus influenzae". J. Biol. Chem. 272 (26): 16555–16563. doi:10.1074/jbc.272.26.16555. PMID 9195966.
- ↑ Lobau, S.; Mamat, U.; Brabetz, W.; Brade, H. (1995). "Molecular cloning, sequence analysis, and functional characterization of the lipopolysaccharide biosynthetic gene kdtA encoding 3-deoxy-α-D-manno-octulosonic acid transferase of Chlamydia pneumoniae strain TW-183". Mol. Microbiol. 18 (3): 391–399. doi:10.1111/j.1365-2958.1995.mmi_18030391.x. PMID 8748024.
External links
- Lipid IVA 3-deoxy-D-manno-octulosonic acid transferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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