Laser Direct Infrared (LDIR) Imaging

Laser Direct Infrared (LDIR) Imaging is an infrared microscopy architecture that utilizes a tunable Quantum Cascade Laser (QCL) as the IR source.[1] This new reflectance-based architecture eliminates coherence artifacts typically associated with QCLs. It also allows the acquisition of large-area, high-definition IR images as well as high signal-to-noise point spectra. Extending this architecture using Attenuated Total Reflectance (ATR) allows the acquisition of high fidelity spectra from features less than 10 μm in size.[2]

The application of LDIR to stain-free biochemical imaging has recently been reported,[3] with the authors citing the speed of LDIR imaging as an advantage over traditional IR imaging architectures.

References

  1. ↑ Hoke, C., Beregovski, Y., Ghetler, A., Han, Y., Moon, C., and Tella, R. (2015) "Laser Direct IR Imaging - A New Paradigm for Mid-IR Spectroscopic Imaging." Proceedings of SciX 2015 (FACSS XLII), Providence, RI, 569. http://www.facss.org/images/pdfs/program/2015_Conf_Program.pdf
  2. ↑ Hoke, C., Beregovski, Y., Ghetler, A., Han, Y., Moon, C., Tella, R., and Zhang, Z. (2016) "Advances in Laser Direct IR Imaging." Proceedings of SciX 2016, Minneapolis, MN, 16IR07. https://www.scixconference.org/program/final-program?symposium=16IR07&p=8298
  3. ↑ Tiwari, S., Raman, J., Reddy, V., Ghetler, A., Tella, R., Han, Y., Moon, C., Hoke, C., and Bhargava, R. (2016) "Towards Translation of Discrete Frequency Infrared Spectroscopic Imaging for Digital Histopathology of Clinical Biopsy Samples." Analytical Chemistry Article ASAP, DOI: 10.1021/acs.analchem.6b02754. http://pubs.acs.org/doi/abs/10.1021/acs.analchem.6b02754
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