L-saccharopine oxidase

L-saccharopine oxidase
Identifiers
EC number 1.5.3.18
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

L-saccharopine oxidase (EC 1.5.3.18, FAP2) is an enzyme with systematic name L-saccharopine:oxygen oxidoreductase (L-glutamate forming).[1][2] This enzyme catalyses the following chemical reaction

N6-(L-1,3-dicarboxypropyl)-L-lysine + H2O + O2 (S)-2-amino-6-oxohexanoate + L-glutamate + H2O2

The enzyme is involved in pipecolic acid biosynthesis.

References

  1. Yoshida, N.; Akazawa, S.; Katsuragi, T.; Tani, Y. (2004). "Characterization of two fructosyl-amino acid oxidase homologs of Schizosaccharomyces pombe". J. Biosci. Bioeng. 97 (4): 278–280. doi:10.1016/S1389-1723(04)70204-2. PMID 16233628.
  2. Wickwire, B.M.; Wagner, C.; Broquist, H.P. (1990). "Pipecolic acid biosynthesis in Rhizoctonia leguminicola. II. Saccharopine oxidase: a unique flavin enzyme involved in pipecolic acid biosynthesis". J. Biol. Chem. 265 (25): 14748–14753. PMID 2394693.
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