Kallikrein 8
| Kallikrein 8 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.21.118 | ||||||||
| CAS number | 171715-15-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Kallikrein 8 (EC 3.4.21.118, KLK8, PRSS19, human kallikrein 8, hK8, mK8, ovasin, tumor-associated differentially expressed gene 14, TADG-14, NP, neuropsin) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction
- Cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys
The enzyme is activated by removal of an N-terminal prepropeptide.
References
- ↑ Chen, Z.L.; Yoshida, S.; Kato, K.; Momota, Y.; Suzuki, J.; Tanaka, T.; Ito, J.; Nishino, H.; Aimoto, S.; Kiyama, H.; Shiosaka, S. (1995). "Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus". J. Neurosci. 15 (7 Pt 2): 5088–5097. PMID 7623137.
- ↑ Shimizu, C.; Yoshida, S.; Shibata, M.; Kato, K.; Momota, Y.; Matsumoto, K.; Shiosaka, T.; Midorikawa, R.; Kamachi, T.; Kawabe, A.; Shiosaka, S. (1998). "Characterization of recombinant and brain neuropsin, a plasticity-related serine protease". J. Biol. Chem. 273 (18): 11189–11196. doi:10.1074/jbc.273.18.11189. PMID 9556608.
- ↑ Rajapakse, S.; Ogiwara, K.; Takano, N.; Moriyama, A.; Takahashi, T. (2005). "Biochemical characterization of human kallikrein 8 and its possible involvement in the degradation of extracellular matrix proteins". FEBS Lett. 579: 6879–6884. doi:10.1016/j.febslet.2005.11.039. PMID 16337200.
- ↑ Kishi, T.; Cloutier, S.M.; Kündig, C.; Deperthes, D.; Diamandis, E.P. (2006). "Activation and enzymatic characterization of recombinant human kallikrein 8". Biol. Chem. 387: 723–731. doi:10.1515/BC.2006.091. PMID 16800733.
External links
- Kallikrein 8 at the US National Library of Medicine Medical Subject Headings (MeSH)
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