Human endogenous retrovirus K endopeptidase

Human endogenous retrovirus K endopeptidase
Identifiers
EC number 3.4.23.50
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Human endogenous retrovirus K endopeptidase (EC 3.4.23.50, human endogenous retrovirus K10 endopeptidase, endogenous retrovirus HERV-K10 putative protease, human endogenous retrovirus K retropepsin, HERV K10 endopeptidase, HERV K10 retropepsin, HERV-K PR, HERV-K protease, HERV-K113 protease, human endogenous retrovirus K113 protease, human retrovirus K10 retropepsin) is an enzyme.[1] This enzyme catalyses the following chemical reaction

Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-PIVQ- cleavage site.

This enzyme belongs to the peptidase family A2.

References

  1. Towler, E.M., Gulnik, S.V., Bhat, T.N., Xie, D., Gustschina, E., Sumpter, T.R., Robertson, N., Jones, C., Sauter, M., Mueller-Lantzsch, N., Debouck, C. and Erickson, J.W. (1998). "Functional characterization of the protease of human endogenous retrovirus, K10: can it complement HIV-1 protease". Biochemistry. 37: 17137–17144. doi:10.1021/bi9818927. PMID 9860826.
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