Histolysain

Histolysain
Identifiers
EC number 3.4.22.35
CAS number 92228-52-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Histolysain (EC 3.4.22.35, histolysin, Entamoeba histolytica cysteine proteinase, amebapain, Entamoeba histolytica cysteine protease, Entamoeba histolytica neutral thiol proteinase) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

Hydrolysis of proteins, including basement membrane collagen and azocasein. Preferential cleavage: Arg-Arg- in small molecule substrates including Z-Arg-Arg-!NHMec

This enzyme is present in the protozoan, Entamoeba histolytica.

References

  1. Lushbaugh, W.B.; Hofbauer, A.F.; Pittman, F.E. (1985). "Entamoeba histolytica: purification of cathepsin B". Exp. Parasitol. 59: 328–336. doi:10.1016/0014-4894(85)90088-8. PMID 2860002.
  2. Luaces, A.L.; Barrett, A.J. (1988). "Affinity purification and biochemical characterization of histolysin: the major cysteine proteinase of Entamoeba histolytica". Biochem. J. 250: 903–909. PMID 2898937.
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