Heparosan-N-sulfate-glucuronate 5-epimerase

Heparosan-N-sulfate-glucuronate 5-epimerase
Identifiers
EC number 5.1.3.17
CAS number 112567-86-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Heparosan-N-sulfate-glucuronate 5-epimerase (EC 5.1.3.17, heparosan epimerase, heparosan-N-sulfate-D-glucuronosyl 5-epimerase, C-5 uronosyl epimerase, polyglucuronate epimerase, D-glucuronyl C-5 epimerase, poly[(1,4)-beta-D-glucuronosyl-(1,4)-N-sulfo-alpha-D-glucosaminyl] glucurono-5-epimerase) is an enzyme with systematic name poly((1->4)-beta-D-glucuronosyl-(1->4)-N-sulfo-alpha-D-glucosaminyl) glucurono-5-epimerase.[1] This enzyme catalyses the following chemical reaction

heparosan-N-sulfate D-glucuronate heparosan-N-sulfate L-iduronate

This enzyme acts on D-glucuronosyl residues adjacent to sulfated D-glucosamine units in the heparin precursor.

See also

References

  1. Jacobsson, I.; Bäckström, G.; Höök, M.; Lindahl, U.; Feingold, D.S.; Malmström, A.; Rodén, L. (1979). "Biosynthesis of heparin. Assay and properties of the microsomal uronosyl C-5 epimerase". J. Biol. Chem. 254: 2975–2982. PMID 107165.
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