Glutathione amide reductase

Glutathione amide reductase
Identifiers
EC number 1.8.1.16
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Glutathione amide reductase (EC 1.8.1.16, GAR) is an enzyme with systematic name glutathione amide:NAD+ oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction

2 glutathione amide + NAD+ glutathione amide disulfide + NADH + H+

Glutathione amide reductase is a dimeric flavoprotein (FAD).

References

  1. Vergauwen, B.; Pauwels, F.; Jacquemotte, F.; Meyer, T.E.; Cusanovich, M.A.; Bartsch, R.G.; Van Beeumen, J.J. (2001). "Characterization of glutathione amide reductase from Chromatium gracile. Identification of a novel thiol peroxidase (Prx/Grx) fueled by glutathione amide redox cycling". J. Biol. Chem. 276: 20890–20897. doi:10.1074/jbc.M102026200. PMID 11399772.
  2. Vergauwen, B.; Van Petegem, F.; Remaut, H.; Pauwels, F.; Van Beeumen, J.J. (2002). "Crystallization and preliminary X-ray crystallographic analysis of glutathione amide reductase from Chromatium gracile". Acta Crystallogr. D. 58 (Pt 2): 339–340. doi:10.1107/s0907444901020303. PMID 11807270.
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