Glutamyl endopeptidase II
| Glutamyl endopeptidase II | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.21.82 | ||||||||
| CAS number | 137010-42-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Glutamyl endopeptidase II (EC 3.4.21.82, GluSGP) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- Preferential cleavage: -Glu- >> -Asp- . Preference for Pro or Leu at P2 and Phe at P3. Cleavage of -Glu-Asp- and -Glu-Pro- bonds is slow
This enzyme is isolated from Streptomyces griseus.
References
- ↑ Yoshida, N.; Tsuruyama, S.; Nagata, K.; Hirayama, K.; Noda, K.; Makisumi, S. (1988). "Purification and characterization of an acidic amino acid specific endopeptidase of Streptomyces griseus obtained from a commercial preparation (Pronase)". J. Biochem. (Tokyo). 104: 451–456. PMID 3149277.
- ↑ Komiyama, T.; Bigler, T.L.; Yoshida, N.; Noda, K.; Laskowski, M. Jr. (1991). "Replacement of P1 Leu18 by Glu18 in the reactive site of turkey ovomucoid third domain converts it into a strong inhibitor of Glu-specific Streptomyces griseus Proteinase (GluSGP)". J. Biol. Chem. 266: 10727–10730. PMID 1674942.
- ↑ Nagata, K.; Yoshida, N.; Ogata, F.; Araki, M.; Noda, K. (1991). "Subsite mapping of an acidic amino acid-specific endopeptidase from Streptomyces griseus, GluSGP, and protease V8". J. Biochem. (Tokyo). 110: 859–862. PMID 1794975.
- ↑ Svendsen, I.; Jensen, M.R.; Breddam, K. (1991). "The primary structure of the glutamic acid-specific protease of Streptomyces griseus". FEBS Lett. 292: 165–167. doi:10.1016/0014-5793(91)80859-2. PMID 1959600.
- ↑ Breddam, K.; Meldal, M. (1992). "Substrate preferences of glutamic-acid-specific endopeptidases assessed by synthetic peptide substrates based on intramolecular fluorescence quenching". Eur. J. Biochem. 206: 103–107. doi:10.1111/j.1432-1033.1992.tb16906.x. PMID 1587264.
External links
- Glutamyl endopeptidase II at the US National Library of Medicine Medical Subject Headings (MeSH)
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