Galactan 5-O-arabinofuranosyltransferase

Galactan 5-O-arabinofuranosyltransferase
Identifiers
EC number 2.4.2.46
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Galactan 5-O-arabinofuranosyltransferase (EC 2.4.2.46, AftA, Rv3792) is an enzyme with systematic name galactofuranan:trans,octacis-decaprenylphospho-beta-D-arabinofuranose 5-O-alpha-D-arabinofuranosyltransferase.[1] This enzyme catalyses the following chemical reaction

Adds an alpha-D-arabinofuranosyl group from trans,octacis-decaprenylphospho-β-D-arabinofuranose at the 5-O-position of the eighth, tenth and twelfth galactofuranose unit of the galactofuranan chain of [beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol

This enzyme is isolated from Mycobacterium tuberculosis and Corynebacterium glutamicum.

References

  1. Alderwick, L.J.; Seidel, M.; Sahm, H.; Besra, G.S.; Eggeling, L. (2006). "Identification of a novel arabinofuranosyltransferase (AftA) involved in cell wall arabinan biosynthesis in Mycobacterium tuberculosis". J. Biol. Chem. 281 (23): 15653–15661. doi:10.1074/jbc.M600045200. PMID 16595677.
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