Fibrolase
| Fibrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.24.72 | ||||||||
| CAS number | 116036-70-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Fibrolase (EC 3.4.24.72, fibrinolytic proteinase, Agkistrodon contortrix contortrix metalloproteinase, Agkistrodon contortrix contortrix venom metalloproteinase) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- Hydrolysis of -Ala14-Leu- in insulin B chain and -Lys413-Leu- in Aalpha-chain of fibrinogen
This enzyme is present in the venom of the southern copperhead snake (Agkistrodon contortrix contortrix).
References
- ↑ Retzios, A.D.; Markland, F.S. Jr. (1988). "A direct-acting fibrinolytic enzyme from the venom of Agkistrodon contortrix contortrix: effects on various components of the human blood coagulation and fibrinolysis systems". Thromb. Res. 52: 541–552. doi:10.1016/0049-3848(88)90127-2. PMID 3232124.
- ↑ Guan, A.L.; Retzios, A.D.; Henderson, G.N.; Markland, F.S. Jr. (1991). "Purification and characterization of a fibrinolytic enzyme from venom of southern copperhead snake (Agkistrodon contortrix contortrix)". Arch. Biochem. Biophys. 289: 197–207. doi:10.1016/0003-9861(91)90462-r. PMID 1898066.
- ↑ Randolph, A.; Chamberlain, S.H.; Chu, H.L.C.; Retzios, A.D.; Markland, F.S. (1992). "Jr. and Masiarz, F.R. Amino acid sequence of fibrolase, a direct-acting fibrinolytic enzyme from Agkistrodon contortrix venom". Protein Sci. 1: 590–600. doi:10.1002/pro.5560010505. PMID 1304358.
- ↑ Loayza, S.L.; Trikha, M.; Markland, F.S.; Riquelme, P.; Kuo, J. (1994). "Resolution of isoforms of natural and recombinant fibrolase, the fibrinolytic enzyme from Agkistrodon contortrix contortrix snake venom, and comparison of their EDTA sensitivities". J. Chromatogr. B Biomed. Appl. 662: 227–243. doi:10.1016/0378-4347(94)00202-9. PMID 7719479.
- ↑ Retzios, A.D.; Markland, F.S. (1994). "Fibrinolytic enzymes from the venoms of Agkistrodon contortrix contortrix and Crotalus basilicus basilicus: cleavage site specificity towards the α-chain of fibrin". Thromb. Res. 74: 355–367. doi:10.1016/0049-3848(94)90151-1. PMID 8085237.
External links
- Fibrolase at the US National Library of Medicine Medical Subject Headings (MeSH)
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