Tubulin GTPase

Tubulin GTPase
Identifiers
EC number 3.6.5.6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Tubulin GTPase (EC 3.6.5.6) is an enzyme with systematic name GTP phosphohydrolase (microtubule-releasing).[1][2][3] This enzyme catalyses the following chemical reaction

GTP + H2O GDP + phosphate

This enzyme participates in tubulin folding and division plane formation.

See also

References

  1. Yu, X.C.; Margolin, W. (1997). "Ca2+-mediated GTP-dependent dynamic assembly of bacterial cell division protein FtsZ into asters and polymer networks in vitro". EMBO J. 16: 5455–5463. doi:10.1093/emboj/16.17.5455. PMID 9312004.
  2. Tian, G.; Bhamidipati, A.; Cowan, N.J.; Lewis, S.A. (1999). "Tubulin folding cofactors as GTPase-activating proteins. GTP hydrolysis and the assembly of the α/β-tubulin heterodimer". J. Biol. Chem. 274: 24054–24058. doi:10.1074/jbc.274.34.24054. PMID 10446175.
  3. Roychowdhury, S.; Panda, D.; Wilson, L.; Rasenick, M.M. (1999). "G protein α subunits activate tubulin GTPase and modulate microtubule polymerization dynamics". J. Biol. Chem. 274: 13485–13490. doi:10.1074/jbc.274.19.13485. PMID 10224115.
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