Pycnoporopepsin

Pycnoporopepsin
Identifiers
EC number 3.4.23.30
CAS number 77967-78-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Pycnoporopepsin (EC 3.4.23.30, proteinase Ia, Pycnoporus coccineus aspartic proteinase, Trametes acid proteinase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Similar to pepsin A, but narrower, cleaving only three bonds in the B chain of insulin: Ala14-Leu, Tyr16-Leu, and Phe24-Phe

This enzyme is isolated from the basidiomycete Pycnoporus sanguineus.

References

  1. Tomoda, K.; Shimazono, H. (1964). "Acid protease produced by Trametes sanguinea a wood-destroying fungus. Part I. Purification and crystallization of the enzyme". Agric. Biol. Chem. 28: 770–773. doi:10.1271/bbb1961.28.770.
  2. Tsuru, D.; Hattori, A.; Tsuji, H.; Yamamoto, T.; Fukumoto, J. (1969). "Studies on mold proteases. Part II. Substrate specificity of acid protease of Rhizopus chinensis". Agric. Biol. Chem. 33: 1419–1426. doi:10.1080/00021369.1969.10859482.
  3. Ichishima, E.; Kumagai, H.; Tomoda, K. (1980). "Substrate specificity of carboxyl proteinase from Pycnoporus coccineus, a wood-deteriorating fungus". Curr. Microbiol. 3: 333–337. doi:10.1007/bf02601897.
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