Exodeoxyribonuclease I
| Exodeoxyribonuclease I | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.11.1 | ||||||||
| CAS number | 9037-46-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Exodeoxyribonuclease I (EC 3.1.11.1, Escherichia coli exonuclease I, E. coli exonuclease I, exonuclease I) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction:
- Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates
Preference for single-stranded DNA. The Escherichia coli enzyme hydrolyses glucosylated DNA. Punjabi
References
- ↑ Blakesley, R.W.; Dodgson, J.B.; Nes, I.F.; Wells, R.D. (1977). "Duplex regions in single-stranded phiX174 DNA are cleaved by a restriction endonuclease from Haemophilus aegyptius". J. Biol. Chem. 252: 7300–7306. PMID 71298.
- ↑ Kelley, R.B.; Atkinson, M.R.; Huberman, J.A.; Kornberg, A. (1969). "Excision of thymine dimers and other mismatched sequences by DNA polymerases of Escherichia coli". Nature. 224: 495–501. doi:10.1038/224495a0.
- ↑ Lehman, I.R.; Nussbaum, A.L. (1964). "The deoxyribonucleases of Escherichia coli. V. On the specificity of exonuclease I (phosphodiesterase)". J. Biol. Chem. 239: 2628–2636. PMID 14235546.
External links
- Exodeoxyribonuclease I at the US National Library of Medicine Medical Subject Headings (MeSH)
This article is issued from Wikipedia - version of the 10/28/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.