Steroid 11beta-monooxygenase

steroid 11-beta-monooxygenase
Identifiers
EC number 1.14.15.4
CAS number 9029-66-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a steroid 11beta-monooxygenase (EC 1.14.15.4) is an enzyme that catalyzes the chemical reaction

a steroid + reduced adrenal ferredoxin + O2 an 11beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O

The 3 substrates of this enzyme are steroid, reduced adrenal ferredoxin, and O2, whereas its 3 products are 11beta-hydroxysteroid, oxidized adrenal ferredoxin, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with reduced iron-sulfur protein as one donor, and incorporation o one atom of oxygen into the other donor. The systematic name of this enzyme class is steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating). Other names in common use include steroid 11beta-hydroxylase, steroid 11beta/18-hydroxylase, and oxygenase, steroid 11beta -mono-. This enzyme participates in c21-steroid hormone metabolism and androgen and estrogen metabolism. It employs one cofactor, heme.

References


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