Diphosphoinositol-polyphosphate diphosphatase

Diphosphoinositol-polyphosphate diphosphatase
Identifiers
EC number 3.6.1.52
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

In enzymology, a diphosphoinositol-polyphosphate diphosphatase (EC 3.6.1.52) is an enzyme that catalyzes the chemical reaction

diphospho-myo-inositol polyphosphate + H2O myo-inositol polyphosphate + phosphate

Thus, the two substrates of this enzyme are diphospho-myo-inositol polyphosphate and H2O, whereas its two products are myo-inositol polyphosphate and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is diphospho-myo-inositol-polyphosphate diphosphohydrolase. Other names in common use include diphosphoinositol-polyphosphate phosphohydrolase, and DIPP.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2DUK, 2FVV, and 2Q9P.

References

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