Dihydroorotate dehydrogenase (quinone)
| Dihydroorotate dehydrogenase (quinone) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.3.5.2 | ||||||||
| CAS number | 59088-23-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Dihydroorotate dehydrogenase (quinone) (EC 1.3.5.2, dihydroorotate:ubiquinone oxidoreductase, (S)-dihydroorotate:(acceptor) oxidoreductase, (S)-dihydroorotate:acceptor oxidoreductase, DHOdehase (ambiguous), DHOD (ambiguous), DHODase (ambiguous), DHODH) is an enzyme with systematic name (S)-dihydroorotate:quinone oxidoreductase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- (S)-dihydroorotate + a quinone orotate + a quinol
This Class 2 dihydroorotate dehydrogenase enzyme contains FMN.
References
- ↑ Forman, H.J.; Kennedy, J. (1978). "Mammalian dihydroorotate dehydrogenase: physical and catalytic properties of the primary enzyme". Arch. Biochem. Biophys. 191 (1): 23–31. doi:10.1016/0003-9861(78)90063-2. PMID 216313.
- ↑ Hines, V.; Keys, L.D. III; Johnston, M. (1986). "Purification and properties of the bovine liver mitochondrial dihydroorotate dehydrogenase". J. Biol. Chem. 261 (24): 11386–11392. PMID 3733756.
- ↑ Bader, B.; Knecht, W.; Fries, M.; Löffler, M. (1998). "Expression, purification, and characterization of histidine-tagged rat and human flavoenzyme dihydroorotate dehydrogenase". Protein Expr. Purif. 13 (3): 414–422. doi:10.1006/prep.1998.0925. PMID 9693067.
- ↑ Fagan, R.L.; Nelson, M.N.; Pagano, P.M.; Palfey, B.A. (2006). "Mechanism of flavin reduction in Class 2 dihydroorotate dehydrogenases". Biochemistry. 45 (50): 14926–14932. doi:10.1021/bi060919g. PMID 17154530.
- ↑ Björnberg, O; Grüner, A.C.; Roepstorff, P.; Jensen, K.F. (1999). "The activity of Escherichia coli dihydroorotate dehydrogenase is dependent on a conserved loop identified by sequence homology, mutagenesis, and limited proteolysis". Biochemistry. 38: 2899–2908. doi:10.1021/bi982352c. PMID 10074342.
External links
- Dihydroorotate dehydrogenase (quinone) at the US National Library of Medicine Medical Subject Headings (MeSH)
This article is issued from Wikipedia - version of the 5/18/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.