Dihydrocarveol dehydrogenase

Dihydrocarveol dehydrogenase
Identifiers
EC number 1.1.1.296
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Dihydrocarveol dehydrogenase (EC 1.1.1.296, carveol dehydrogenase (ambiguous)) is an enzyme with systematic name menth-8-en-2-ol:NAD+ oxidoreductase.[1] This enzyme catalyses the following chemical reaction

menth-8-en-2-ol + NAD+ menth-8-en-2-one + NADH + H+

This enzyme from the Gram-positive bacterium Rhodococcus erythropolis DCL14 forms part of the carveol and dihydrocarveol degradation pathway. The enzyme accepts all eight stereoisomers of menth-8-en-2-ol as substrate, although some isomers are converted faster than others. The preferred substrates are (+)-neoisodihydrocarveol, (+)-isodihydrocarveol, (+)-dihydrocarveol and (-)-isodihydrocarveol.

References

  1. van der Werf; M. J. and Boot; A. M. (2000). "Metabolism of carveol and dihydrocarveol in Rhodococcus erythropolis DCL14". Microbiology. 146: 1129–1141. doi:10.1099/00221287-146-5-1129. PMID 10832640.

External links

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