Diadenosine hexaphosphate hydrolase (ATP-forming)

Diadenosine hexaphosphate hydrolase (ATP-forming)
Identifiers
EC number 3.6.1.61
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Diadenosine hexaphosphate hydrolase (ATP-forming) (EC 3.6.1.61, Ndx1) is an enzyme with systematic name P1,P6-bis(5'-adenosyl)hexaphosphate nucleotidohydrolase (ATP-forming).[1] This enzyme catalyses the following chemical reaction

(1) P1,P6-bis(5'-adenosyl)hexaphosphate + H2O 2 ATP
(2) P1,P5-bis(5'-adenosyl)pentaphosphate + H2O ATP + ADP
(3) P1,P4-bis(5'-adenosyl)tetraphosphate + H2O ATP + AMP

The enzyme requires the presence of the divalent cations (Mn2+, Mg2+, Zn2+, and Co2+).

References

  1. Iwai, T.; Kuramitsu, S.; Masui, R. (2004). "The Nudix hydrolase Ndx1 from Thermus thermophilus HB8 is a diadenosine hexaphosphate hydrolase with a novel activity". J. Biol. Chem. 279: 21732–21739. doi:10.1074/jbc.m312018200. PMID 15024014.

External links

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