Deoxyribonuclease (pyrimidine dimer)

Deoxyribonuclease (pyrimidine dimer)
Identifiers
EC number 3.1.25.1
CAS number 66143-22-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Deoxyribonuclease (pyrimidine dimer) (EC 3.1.25.1, endodeoxyribonuclease (pyrimidine dimer), bacteriophage T4 endodeoxyribonuclease V, T4 endonuclease V) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

Endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate

This enzyme acts on a damaged strand, 5' from the damaged site.

References

  1. Braun, A.G.; Radman, M.; Grossman, L. (1976). "Enzymic repair of DNA: sites of hydrolysis by the Escherichia coli endonuclease specific for pyrimidine dimers (corendonuclease II)". Biochemistry. 15 (18): 4116–4120. doi:10.1021/bi00663a031. PMID 786366.
  2. Riazuddin, S.; Grossman, L. (1977). "Micrococcus luteus correndonucleases. II. Mechanism of action of two endonucleases specific for DNA containing pyrimidine dimers". J. Biol. Chem. 252 (18): 6287–6293. PMID 330526.

External links

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