Demethylrebeccamycin-D-glucose O-methyltransferase

Demethylrebeccamycin-D-glucose O-methyltransferase
Identifiers
EC number 2.1.1.164
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Demethylrebeccamycin-D-glucose O-methyltransferase (EC 2.1.1.164, RebM) is an enzyme with systematic name S-adenosyl-L-methionine:demethylrebeccamycin-D-glucose O-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction

4'-demethylrebeccamycin + S-adenosyl-L-methionine rebeccamycin + S-adenosyl-L-homocysteine

Demethylrebeccamycin-D-glucose O-methyltransferase catalyses the last step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the Actinobacterium Lechevalieria aerocolonigenes.

References

  1. Zhang, C.; Albermann, C.; Fu, X.; Peters, N.R.; Chisholm, J.D.; Zhang, G.; Gilbert, E.J.; Wang, P.G.; Van Vranken, D.L.; Thorson, J.S. (2006). "RebG- and RebM-catalyzed indolocarbazole diversification". Chembiochem. 7 (5): 795–804. doi:10.1002/cbic.200500504. PMID 16575939.
  2. Singh, S.; McCoy, J.G.; Zhang, C.; Bingman, C.A.; Phillips, G.N.; Jr.; Thorson, J.S. (2008). "Structure and mechanism of the rebeccamycin sugar 4-O-methyltransferase RebM". J. Biol. Chem. 283 (33): 22628–22636. doi:10.1074/jbc.M800503200. PMC 2504894Freely accessible. PMID 18502766.

External links

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