Acyl-CoA dehydrogenase (NADP+)

Structure of Crotonyl CoA carboxylase/reductase. From Streptomycs collinus.[1]
acyl-CoA dehydrogenase (NADP+)
Identifiers
EC number 1.3.1.8
CAS number 37251-07-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, an acyl-CoA dehydrogenase (NADP+) (EC 1.3.1.8) is an enzyme that catalyzes the chemical reaction

acyl-CoA + NADP+ 2,3-dehydroacyl-CoA + NADPH + H+

Thus, the two substrates of this enzyme are acyl-CoA and NADP+, whereas its 3 products are 2,3-dehydroacyl-CoA, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is acyl-CoA:NADP+ 2-oxidoreductase. Other names in common use include 2-enoyl-CoA reductase, dehydrogenase, acyl coenzyme A (nicotinamide adenine dinucleotide, phosphate), enoyl coenzyme A reductase, crotonyl coenzyme A reductase, crotonyl-CoA reductase, and acyl-CoA dehydrogenase (NADP+).

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1YXM.

References

  1. PDB: 3HZZ; Scarsdale, J.N.; Musayev, F.N.; Hazzard, C.; Florova, G.; Reynolds, K.; Wright, H.T. (2010). "Structure of Streptomycs collinus crotonyl COA carboxylase/reductase". To be Published. doi:10.2210/pdb3hzz/pdb.; rendered using PyMOL.


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